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EPICENTRE Technologies Corporation (hereinafter "EPICENTRE") agrees to sell its products under the Terms and Conditions below.

Prices quoted are for orders sent as a single shipment. Payment Terms are net 30 days. Thereafter, a carrying charge of 1.5% per month will be added to the unpaid balance.

By purchasing EPICENTRE's products, the organization that orders or buys products from EPICENTRE (hereinafter"PURCHASER") agrees to the Terms and Conditions herein. These Terms and Conditions cannot be superseded without express written agreement by an officer of EPICENTRE. EPICENTRE's failure to object to provisions contained in any purchase order or other form or document from PURCHASER shall not be construed as a waiver of these Terms and Conditions nor an acceptance of any such provision. PURCHASER agrees to hold harmless and indemnify EPICENTRE and its employees from and against any and all claims, losses, damages or other liability, including reasonable attorneys' fees, resulting from a use of the purchased products that is not in accordance with these Terms and Conditions.

Product Use

EPICENTRE's products are for research or laboratory use only and are not to be administered to humans or animals or used for pharmaceutical, in vitro diagnostic, or commercial purposes without written permission. Inquiries related to additional uses of EPICENTRE's products are welcomed.

EPICENTRE shall not be responsible for injury or damages resulting from the use or misuse of any of its products. Persons using the products should be technically qualified as defined in 40 C.F.R. § 720.3(ee) and should follow the Guidelines for Research involving Recombinant DNA Molecules (N.I.H. Guidelines) as presented in the Federal Register, July 5, 1994 (59 FR 34496) and any amendments thereto.

Warranty

EPICENTRE warrants that its products will conform to the standards stated in its product specification sheets in effect at the time of shipment. EPICENTRE will replace, free of charge, any product that does not conform to the specifications. This warranty limits EPICENTRE's liability only to the replacement of the product. THIS WARRANTY IS EXCLUSIVE, AND EPICENTRE MAKES NO OTHER WARRANTY, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION, ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. The stated express warranties, and the remedy provided for breach thereof, are in lieu of all other liability or obligations of EPICENTRE for any damages whatsoever arising out of or in connection with the delivery, use, performance, or the inability to use any of its products. IN NO EVENT SHALL EPICENTRE BE LIABLE UNDER ANY LEGAL THEORY (INCLUDING BUT NOT LIMITED TO CONTRACT,
NEGLIGENCE, STRICT LIABILITY IN TORT, OR WARRANTY OF ANY KIND) FOR ANY INDIRECT, SPECIAL, INCIDENTAL, CONSEQUENTIAL, OR EXEMPLARY DAMAGES (INCLUDING BUT NOT LIMITED TO LOST PROFITS). Without limiting the effect of the preceding sentence, EPICENTRE's maximum liability, if any, shall not exceed the purchase price paid by PURCHASER for the product.

Patent Disclaimer

Unless explicitly stated, no license or immunity under any patent is either granted or implied by the sale of any of EPICENTRE's products. EPICENTRE does not warrant that the resale or use of its products delivered will not infringe the claims of any United States or other patents, trademarks, or copyright covering the product itself, or its use in combination with other products, or in the operation of any process, and PURCHASER assumes all risks of patent, trademark, or copyright infringement by reason of any such use, combination, or operation.

Disclaimer

EPICENTRE shall not be responsible for injury or damages resulting from the use or misuse of any of its products.

Product Changes

EPICENTRE reserves the right to discontinue the sale of any product or to make changes in any product at any time without notice.

Patents, Licenses, and Trademarks

Use of Betaine for DNA Polymerase Reactions, including, but not limited to, use for PCR or DNA Sequencing, is covered by U.S. Patent No. 6,270,962, European Patent No. 0742838, German Patent No. DE4411588C1, and other issued or pending applications in the U.S. and other countries that are either assigned or exclusively licensed to EPICENTRE. These products are accompanied by a limited non-exclusive license for the purchaser to use the purchased products solely for life science research. Contact EPICENTRE for information on licenses for uses in diagnostics or other fields.

Circligase™ ssDNA Ligase is covered by intellectual property rights licensed to EPICENTRE. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product in research conducted by the buyer. The buyer cannot sell or otherwise transfer this product or its components to a third party and in particular, no rights are conveyed to the buyer to use the product or its components for commercial use purpose other than for research to gain information that is used by the buyer.

CopyControl™ Products are covered by U.S. Patent No. 5,874,259 licensed to EPICENTRE and by other patents pending and assigned to EPICENTRE for specific CopyControl vectors and/or cell lines. By purchasing CopyControl systems or vectors, the purchaser receives the right to use the product purchased from EPICENTRE or clones obtained therefrom solely for life science research. Purchase of these products does not grant rights to: (1) offer products, components of products, or any derivatives thereof for resale; or (2) to distribute or transfer the products, components of products, or derivatives thereof to third parties.

CopyCutter™ E. coli Cells are covered by one or more patent applications assigned to EPICENTRE. These products are accompanied by a limited non-exclusive license for the purchaser to use the purchased products solely for life science research. Purchase of these products does not grant rights to: (1) offer products, components of products or any derivatives thereof for resale; or (2) to distribute or transfer the products, components of products, or any derivatives thereof to third parties. Contact EPICENTRE concerning licenses for other uses.

7-Deaza-dGTP is licensed from Boehringer Mannheim GmbH for research purposes only under U.S. Patent No. 4,804,748 and European Patent No. 0212536.

EZ-Tn5™ Transposon Tools for in vitro transposon insertion are covered by U.S. Patent Nos. 5,925,545; 5,948,622; 5,965,443; European Patent No. 0927258, and other patents issued or pending, exclusively licensed or assigned to EPICENTRE. These products are accompanied by a limited non-exclusive license for the purchaser to use the purchased product(s) solely for in vitro transposon insertion for life science research. Purchase of these products does not grant rights to: (1) offer products, components of products, or any derivatives thereof for resale; or (2) to distribute or transfer the products, components of products, or any derivatives thereof to third parties. Contact EPICENTRE for information on licenses for uses other than life science research.

Hybridase™ Thermostable RNase H is covered by U.S. Patent Nos. 5,268,289; 5,459,055; and 5,500,370 assigned to EPICENTRE. This product is accompanied by a limited non-exclusive license for the purchaser to use the purchased product solely for life science research. Contact EPICENTRE for information on licenses to other uses.

Use of Kool™ Templates in Rolling Circle Transcription reactions is covered by U.S. Patents Nos. 5,714,320; 6,077,668; 6,096,880; 6,368,802; and other patents pending in the U.S. and foreign countries, licensed or assigned to EPICENTRE. These products are accompanied by a limited non-exclusive license for the purchaser to use the purchased product(s) solely for life science research. Contact EPICENTRE concerning licenses for other uses.

MasterAmp™ Extra-Long PCR Kit is covered by U.S. Patent No. 5,436,149 and other patents issued or pending worldwide, owned by Takara Shuzo, Co., Ltd. and non-exclusively licensed to EPICENTRE.

MiniV™ Transcription Products are covered by U.S. and international patent applications exclusively licensed to EPICENTRE. These products are accompanied by a limited non-exclusive license for the purchaser to use the purchased product(s) solely for life science research. Contact EPICENTRE concerning licenses for other uses.

The Polymerase Chain Reaction (PCR) process is covered by patents owned by the Hoffmann-LaRoche Corp. Use of the PCR process requires a license. See below: 1. Licensed Research Products designed and sold for use in Amplification Patent Rights. Notice to Purchaser: Limited License. A license under US Patents, 4,683,202, 4,683,195, and 4,965,188 or their foreign counterparts, owned by Hoffmann-La Roche Inc. and F. Hoffmann-La Roche Ltd. ("Roche"), has an up-front fee component and a running-royalty component. The purchase price of this product includes limited, nontransferable rights under the running-royalty component to use only this amount of the product to practice the Polymerase Chain Reaction ("PCR") and related processes described in said patents soley for the research and development activities of the purchaser when this product is used in conjunction with a thermal cycler whose use is covered by the up-front fee component. Rights to the up-front fee component must be obtained by the end user to have a complete license. These rights under the up-front fee component may be purchased from Applied Biosystems or obtained by purchasing an Authorized Thermal Cycler. No right to perform or offer commercial services of any kind using PCR, including without limitation reporting the results of purchaser’s activities for a fee or other commercial consideration, is hereby granted by implication or estoppel. Further information on purchasing licenses to practice the PCR Process may be obtained by contacting the Director of Licensing at Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404 or at Roche Molecular Systems, Inc., 1145 Atlantic Avenue, Alameda, California 94501 and outside the US at F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. 2. For use on research products which are not Licensed Research Products but which are supported for use in PCR and/or with Licensed Research Products. Notice to Purchaser: This product is optimized for use in the Polymerase Chain Reaction ("PCR") covered by patents owned by Hoffmann-La Roche Inc. and F. Hoffmann-La Roche Ltd. ("Roche"). No license under these patents to use the PCR Process is conveyed expressly or by implication to the purchaser by the purchase of this product. A license to use the PCR Process for certain research and development activities accompanies the purchase of certain reagents from licensed suppliers such as EPICENTRE when used in conjunction with an authorized thermal cycler, or is available from Applied Biosystems. Further information on purchasing licenses to practice the PCR Process may be obtained by contacting the Director of Licensing at Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404 or at Roche Molecular Systems, Inc., 1145 Atlantic Avenue, Alameda, California 94501 and outside the US at F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

SYBR® Green I Dye is covered by issued and pending patents owned by Molecular Probes, Inc., Eugene, OR. Products containing SYBR® Green I Dye are licensed by EPICENTRE for use in enzyme-based nucleic acid amplification procedures, including real-time PCR, solely for life science research.

T7 & SP6 R&DNA™ Polymerases, & DuraScribe™ T7 & SP6 Transcription Kits to synthesize nucleic acids with non-canonical bases or for partial ribosubstitution are covered by U.S. Patents 5,849,546; 6,107,037; or 6,596,494, and other patents issued or pending. These products are accompanied by a limited non-exclusive license for the purchaser to use the purchased product(s) solely for life science research. Contact EPICENTRE concerning licenses for other uses.

TargetAmp™ aRNA Amplification Products are covered by intellectual property licensed to EPICENTRE Technologies Corporation from Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

TargetAmp™ aRNA Amplification Products are covered by U.S Patents licensed exclusively to Incyte Corporation and sublicensed to EPICENTRE. The purchase of these products conveys to the buyer the limited, non-exclusive, non-transferable right (without the right to resell, repackage, or further sublicense) under those patents to perform the RNA amplification methods claimed in those patents for research and development purposes, including clinical development of pharmaceutical and diagnostic products and services, solely in conjunction with these products. No other license is granted to the buyer whether expressly, by implication, by estoppel or otherwise. In particular, no rights are conveyed to the buyer to use the products or components of the products for purposes including but not limited to provision of services to a third party, generation of commercial databases or clinical diagnostics. These products are sold pursuant to authorization from Incyte Corporation and Incyte Corporation reserves all other rights under these patents. For information on purchasing a license to the patents of Incyte Corporation for uses other than in conjunction with this product or to use this product for purposes other than research, please contact Incyte Corporation Licensing, Experimental Station, Building 336, Route 141 and Henry Clay Road, Wilmington, DE 19880. Phone 302-498-6700.

Use of Transposome™ Complexes for in vivo Transposon Insertion, including, but not limited to EZ-Tn5™ and HyperMu™ Transposome™ complexes, is covered by U.S. Patent Nos. 6,159,736, and 6,294,385; European Patent No. 1115856 and other patents issued or pending, exclusively licensed to EPICENTRE. These products are accompanied by a limited non-exclusive license for nonprofit organizations to use the purchased products solely for life science research. Specifically, researchers at nonprofit organizations may use these products in their research and they may transfer derivatives of the products to colleagues at other nonprofit organizations provided that such colleagues agree in writing to be bound by the terms and conditions of this label license. Researchers may not transfer these products or its derivatives to researchers at other organizations that are not nonprofit organizations without the express written consent of EPICENTRE and without those entities having an express license from EPICENTRE for the use of the products. Other than as specifically provided here, an authorized transferee of these products shall have no right to transfer these products or its derivatives to any other person or entity. A nonprofit organization performing research using this product for a for-profit organization shall also be considered for-profit. For-profit entities purchasing these products shall have six (6) months to evaluate the products in their research. Thereafter, such for-profit entities shall either contact EPICENTRE and take a license for their continued use of the products or destroy the products and all derivatives thereof. Please contact EPICENTRE with respect to licenses for commercial use, including manufacturing, therapeutic, or diagnostic use.

Trademarks

The following are registered trademarks or trademarks of EPICENTRE:

EPICENTRE®, Ampligase®, and DuraScribe®, 2-Way, AmpliCap, AmpliCap-MAX, AmpliScribe, AmpliTherm, APex, A-Plus, ArrayPure, BACMAX, BAC-Tracker, BuccalAmp, Catch-All, CircLigase, Colony Fast-Screen, CopyControl, CopyCutter, DuraScript, EC100, EC100D, EPI300, EPI400, EasyLyse, End-It, EpiBlue, EpiFOS, Epi-Grids, EpiLyse, ExtractMaster, EZ::TN, EZ-Tn5, FailSafe, Fast-Link, Fast-Screen, FosmidMAX, GELase, HK, Hybridase, HyperMu, IsoTherm, Kool, Long-Read, OmniCleave, MasterAmp, MasterPure, MaxPlax, MessageMAX, MessageMuter, MiniV, MonsterScript, mRNA-ONLY, Mu-End, NC-45, NTPhos, pCC1, pCC1BAC, pCC1FOS, PCRLyse, PeriPreps, PlasmidMAX, Plasmid-Safe, pEpiFOS, pMOD, pPDM, pWEB, pWEB-TNC, QuickExtract, R&DNA, Ready-Lyse, ReadyPreps, RepliPHI, Restricti-Lyse, RetroAmp, RiboScribe, RiboShredder, SequiTherm, SequiTherm EXCEL, SoilMaster, T3-Flash, T7-Flash, Tagetin, TAQurate, TargetAmp, Terminator, TransforMax, Transposome, Transposomics, TypeOne, WaterMaster, ExactStart, Nano-g, TAQXpedite, Baseline-ZERO, mScript, ScriptCap, ScriptGuard, MessageBOOSTER.

The following are trademarks or registered trademarks of the respective organizations:

Affymetrix, Inc. - Affymetrix®, Geneship®
Amersham Biosciences - ALF™, CodeLink®
Amersham Pharmacia Biotech - Cy®
Applied Biosystems - ABI PRISM®
Bio-Rad Laboratories, Inc. - IQ™
Eppendorf AG - Prime RNase Inhibitor™
Invitrogen Corporation - SuperScript™
Kreatech Holding B.V. - ULS™
Li-Cor, Inc. - e-Seq™, Global IR2™, LI-COR®
Merck KGaA - Benzonase®
Molecular Probes, Inc. - Alexa®, RiboGreen®, SYBR®
NEN Life Science Products, Inc. - NEN®
Promega Corporation - pGEM®, RNasin®
Qiagen – RNeasy®
Roche Molecular Systems, Inc. - AmpliTaq®
Rohm & Haas, Co. - Triton®
Stratagene Corporation - pBluescript®

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EPICENTRE® Biotechnologies—Enzyme Systems for RNA and DNA Research
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